Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 18 June 2004:
Vol. 304. no. 5678, p. 1713
DOI: 10.1126/science.304.5678.1713g
|
|
This Week in Science
The propagation of invasive bacteria and mycobacteria is tightly linked to their ability to withstand delivery to the degradative compartment of the cell, the lysosome. Walburger et al. (p. 1800, published online 20 May 2004) identify a mycobacterial protein involved in the modulation of phagosome-lysosome trafficking. Protein kinase G, a eukaryotic-like serine/threonine kinase from the pathogenic mycobacteria, M. tuberculosis, is responsible for inhibiting phagosome-lysosome fusion, promoting mycobacterial survival inside macrophages. Hernandez et al. (p. 1805) find that Salmonella, the food-poisoning and typhoid fever bacterium, modulates vesicular trafficking by altering phosphoinositide metabolism through SopB, a phosphoinositide phosphatase. SopB is delivered into host cells by an invasion-associated specialized secretion system, and mediates the formation of a characteristic very spacious phagosome within which Salmonella resides after internalization. In the absence of SopB, invading Salmonella reside within tight phagosomes, and exhibit a membrane trafficking defect and impaired bacterial intracellular growth.
|
|
Science. ISSN 0036-8075 (print), 1095-9203 (online)
