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How do axons in the developing central nervous system know when and how to cross the midline to reach their neuronal targets on the other side. In his Perspective, Woods discusses the latest finding that the Robo3 receptor expressed by the growing axon tip releases inhibition of the chemoattractant Netrin, resulting in attraction of the axon tip to the midline (Jen et al.). Once the axon tip has crossed the midline, decreased expression of the Robo3 receptor ensures that the tip does not recross the midline.
The author is a Wellcome Trust Fellow and in the Molecular Medicine Unit, School of Medicine, University of Leeds, LS9 7TF, UK. E-mail: msjcgw{at}leeds.ac.uk
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Joanna C. Jen, Wai-Man Chan, Thomas M. Bosley, Jijun Wan, Janai R. Carr, Udo Rüb, David Shattuck, Georges Salamon, Lili C. Kudo, Jing Ou, Doris D. M. Lin, Mustafa A. M. Salih, Tülay Kansu, Hesham al Dhalaan, Zayed al Zayed, David B. MacDonald, Bent Stigsby, Andreas Plaitakis, Emmanuel K. Dretakis, Irene Gottlob, Christina Pieh, Elias I. Traboulsi, Qing Wang, Lejin Wang, Caroline Andrews, Koki Yamada, Joseph L. Demer, Shaheen Karim, Jeffry R. Alger, Daniel H. Geschwind, Thomas Deller, Nancy L. Sicotte, Stanley F. Nelson, Robert W. Baloh, and Elizabeth C. Engle (4 June 2004) Science304 (5676), 1509.
[DOI: 10.1126/science.1096437] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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