Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Policy Alerts

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 May 2004:
Vol. 304. no. 5674, pp. 1120 - 1122
DOI: 10.1126/science.1098966
Prev | Table of Contents | Next

Perspectives

BIOMEDICINE:
Parkinson's--Divergent Causes, Convergent Mechanisms

J. Timothy Greenamyre and Teresa G. Hastings

Parkinson's disease is a progressive neurodegenerative disorder in which there is loss of dopaminergic neurons of the nigrostriatal pathway. Both genetic and environmental causes have been implicated. In their Perspective, Greenamyre and Hastings discuss the different possible causes of PD in light of new work identifying mutations in the putative mitochondrial protein kinase PINK1 as a cause of familial PD (Valente et al.).

J. T. Greenamyre is in the Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. T. G. Hastings is in the Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. E-mail: jgreena{at}emory.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Parkinson disease, 10 years after its genetic revolution: Multiple clues to a complex disorder.
C. Klein and M. G. Schlossmacher (2007)
Neurology 69, 2093-2104
   Abstract »    Full Text »    PDF »
Neuroprotective Effect of Protein Kinase C{delta} Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease.
D. Zhang, V. Anantharam, A. Kanthasamy, and A. G. Kanthasamy (2007)
J. Pharmacol. Exp. Ther. 322, 913-922
   Abstract »    Full Text »    PDF »
The Relationship of Parkinson Disease With Aging.
G. Levy (2007)
Arch Neurol 64, 1242-1246
   Abstract »    Full Text »    PDF »
Merging Mouse Transcriptome Analyses with Parkinson's Disease Linkage Studies.
D. Gherbassi, L. Bhatt, S. Thuret, and H. H. Simon (2007)
DNA Res
   Abstract »    Full Text »    PDF »
Synaptic Activation of Dendritic AMPA and NMDA Receptors Generates Transient High-Frequency Firing in Substantia Nigra Dopamine Neurons In Vitro.
S. N. Blythe, J. F. Atherton, and M. D. Bevan (2007)
J Neurophysiol 97, 2837-2850
   Abstract »    Full Text »    PDF »
DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers.
C. F. Lippa, J. E. Duda, M. Grossman, H. I. Hurtig, D. Aarsland, B. F. Boeve, D. J. Brooks, D. W. Dickson, B. Dubois, M. Emre, et al. (2007)
Neurology 68, 812-819
   Abstract »    Full Text »    PDF »
Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease..
L.M.L. de Lau, P. J. Koudstaal, J. C.M. Witteman, A. Hofman, and M. M.B. Breteler (2006)
Neurology 67, 315-318
   Abstract »    Full Text »    PDF »
Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice..
R. Mejias, J. Villadiego, C. O. Pintado, P. J. Vime, L. Gao, J. J. Toledo-Aral, M. Echevarria, and J. Lopez-Barneo (2006)
J. Neurosci. 26, 4500-4508
   Abstract »    Full Text »    PDF »
Lewy bodies.
C. W. Shults (2006)
PNAS 103, 1661-1668
   Abstract »    Full Text »    PDF »
Framework For Environmental Exposure Research: The Disease-First Approach.
S. H. Wilson and W. A. Suk (2005)
Mol. Interv. 5, 262-267
   Full Text »    PDF »
Dietary fatty acids and the risk of Parkinson disease: The Rotterdam Study.
L.M.L. de Lau, M. Bornebroek, J. C.M. Witteman, A. Hofman, P. J. Koudstaal, and M. M.B. Breteler (2005)
Neurology 64, 2040-2045
   Abstract »    Full Text »    PDF »
Dopamine-derived Dopaminochrome Promotes H2O2 Release at Mitochondrial Complex I: STIMULATION BY ROTENONE, CONTROL BY Ca2+, AND RELEVANCE TO PARKINSON DISEASE.
F. Zoccarato, P. Toscano, and A. Alexandre (2005)
J. Biol. Chem. 280, 15587-15594
   Abstract »    Full Text »    PDF »
Progression of Parkinson Disease: Are We Making Progress in Charting the Course?.
J. Jankovic (2005)
Arch Neurol 62, 351-352
   Full Text »    PDF »
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and {alpha}-synuclein.
F. Fornai, O. M. Schluter, P. Lenzi, M. Gesi, R. Ruffoli, M. Ferrucci, G. Lazzeri, C. L. Busceti, F. Pontarelli, G. Battaglia, et al. (2005)
PNAS 102, 3413-3418
   Abstract »    Full Text »    PDF »
Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation.
K. L. Lim, K. C. M. Chew, J. M. M. Tan, C. Wang, K. K. K. Chung, Y. Zhang, Y. Tanaka, W. Smith, S. Engelender, C. A. Ross, et al. (2005)
J. Neurosci. 25, 2002-2009
   Abstract »    Full Text »    PDF »
Inflammation, Neurodegenerative Diseases, and Environmental Exposures.
A. CAMPBELL (2004)
Ann. N.Y. Acad. Sci. 1035, 117-132
   Abstract »    Full Text »    PDF »
Loss of locus coeruleus neurons and reduced startle in parkin null mice.
R. von Coelln, B. Thomas, J. M. Savitt, K. L. Lim, M. Sasaki, E. J. Hess, V. L. Dawson, and T. M. Dawson (2004)
PNAS 101, 10744-10749
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)