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Science 21 May 2004:
Vol. 304. no. 5674, pp. 1120 - 1122
DOI: 10.1126/science.1098966
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Perspectives

BIOMEDICINE:
Parkinson's--Divergent Causes, Convergent Mechanisms

J. Timothy Greenamyre and Teresa G. Hastings

Parkinson's disease is a progressive neurodegenerative disorder in which there is loss of dopaminergic neurons of the nigrostriatal pathway. Both genetic and environmental causes have been implicated. In their Perspective, Greenamyre and Hastings discuss the different possible causes of PD in light of new work identifying mutations in the putative mitochondrial protein kinase PINK1 as a cause of familial PD (Valente et al.).

J. T. Greenamyre is in the Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. T. G. Hastings is in the Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. E-mail: jgreena{at}emory.edu

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