Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Originally published in Science Express on 18 March 2004
Science 9 April 2004:
Vol. 304. no. 5668, pp. 223 - 224
DOI: 10.1126/science.1097439
Prev | Table of Contents | Next

Perspectives

BIOCHEMISTRY:
Oily Barbarians Breach Ion Channel Gates

Donald W. Hilgemann

It has long been debated whether and how voltage-gated ion channels are affected by the lipid environment of the plasma membrane. In his Perspective, Hilgemann discusses new work (Oliver et al.) showing that the inactivation of voltage-gated potassium (Kv) channels can be modulated by the lipids PIP2 and arachidonic acid.

The author is in the Department of Physiology, University of Texas Southwestern, Dallas, TX 75235, USA. E-mail: donald.hilgemann{at}utsouthwestern.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Close Encounters of the Oily Kind: Regulation of Transporters by Lipids.
C. B. Divito and S. G. Amara (2009)
Mol. Interv. 9, 252-262
   Abstract »    Full Text »    PDF »
Phosphatidylinositol (4,5)Bisphosphate Inhibits K+-Efflux Channel Activity in NT1 Tobacco Cultured Cells.
X. Ma, O. Shor, S. Diminshtein, L. Yu, Y. J. Im, I. Perera, A. Lomax, W. F. Boss, and N. Moran (2009)
Plant Physiology 149, 1127-1140
   Abstract »    Full Text »    PDF »
Splice Variant-Dependent Regulation of {beta}-Cell Sodium-Calcium Exchange by Acyl-Coenzyme As.
K. S. C. Hamming, M. J. Riedel, D. Soliman, L. C. Matemisz, N. J. Webster, G. J. Searle, P. E. MacDonald, and P. E. Light (2008)
Mol. Endocrinol. 22, 2293-2306
   Abstract »    Full Text »    PDF »
Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-Gated Calcium Channel Function in Pancreatic {beta}-Cells.
F. Xia, L. Xie, A. Mihic, X. Gao, Y. Chen, H. Y. Gaisano, and R. G. Tsushima (2008)
Endocrinology 149, 5136-5145
   Abstract »    Full Text »    PDF »
Binding and direct activation of the epithelial Na+ channel (ENaC) by phosphatidylinositides.
O. Pochynyuk, Q. Tong, A. Staruschenko, and J. D. Stockand (2007)
J. Physiol. 580, 365-372
   Abstract »    Full Text »    PDF »
Direct Modulation of Kir Channel Gating by Membrane Phosphatidylinositol 4,5-Bisphosphate.
D. Enkvetchakul, I. Jeliazkova, and C. G. Nichols (2005)
J. Biol. Chem. 280, 35785-35788
   Abstract »    Full Text »    PDF »
Frequency-dependent regulation of cardiac Na+/Ca2+ exchanger.
A. Omelchenko, R. Bouchard, S. Shurraw, M. Trac, M. Hnatowich, and L. V. Hryshko (2005)
Am J Physiol Heart Circ Physiol 289, H1594-H1603
   Abstract »    Full Text »    PDF »
The Phosphatidylinositol 3-Phosphate Phosphatase Myotubularin- Related Protein 6 (MTMR6) Is a Negative Regulator of the Ca2+-Activated K+ Channel KCa3.1.
S. Srivastava, Z. Li, L. Lin, G. Liu, K. Ko, W. A. Coetzee, and E. Y. Skolnik (2005)
Mol. Cell. Biol. 25, 3630-3638
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)