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Science 9 April 2004:
Vol. 304. no. 5668, pp. 192 - 194
DOI: 10.1126/science.304.5668.192
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News Focus

CELL THERAPY:
Renovating the Heart

Jennifer Couzin and Gretchen Vogel

Inspired by reports that cell infusions can heal animal hearts, cardiologists are rapidly moving to test the idea in humans. Even believers can't explain how or why it might work.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Material-based deployment enhances efficacy of endothelial progenitor cells.
E. A. Silva, E.-S. Kim, H. J. Kong, and D. J. Mooney (2008)
PNAS 105, 14347-14352
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Intramyocardial bone marrow stem cell treatment for myocardial regeneration.
G. Steinhoff, Y.-H. Choi, and C. Stamm (2006)
Eur. Heart J. Suppl. 8, H32-H39
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Controversies in cardiothoracic surgery: Should therapeutic cloning be supported to provide stem cells for cardiothoracic surgery research and treatment?.
M. McKneally (2006)
J. Thorac. Cardiovasc. Surg. 131, 937-940
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Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement.
M. Gnecchi, H. He, N. Noiseux, O. D. Liang, L. Zhang, F. Morello, H. Mu, L. G. Melo, R. E. Pratt, J. S. Ingwall, et al. (2006)
FASEB J 20, 661-669
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Predominant fusion of bone marrow-derived cardiomyocytes.
J. Andrade, J. T. Lam, M. Zamora, C. Huang, D. Franco, N. Sevilla, P. J. Gruber, J. T. Lu, and P. Ruiz-Lozano (2005)
Cardiovasc Res 68, 387-393
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Enhancing Stem Cell Therapy Through Genetic Modification.
V. J. Dzau, M. Gnecchi, and A. S. Pachori (2005)
J. Am. Coll. Cardiol. 46, 1351-1353
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Transcriptional Regulation of Cardiac Progenitor Cell Populations.
A. M. Masino, T. D. Gallardo, C. A. Wilcox, E. N. Olson, R. S. Williams, and D. J. Garry (2004)
Circ. Res. 95, 389-397
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