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Science 26 March 2004:
Vol. 303. no. 5666, pp. 1986 - 1987
DOI: 10.1126/science.1096747
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Perspectives

NEUROSCIENCE:
Synaptic Vesicles in the Fast Lane

Matthew Holt and Reinhard Jahn

It is well established that a subset of synaptic vesicles seem to be preferentially recycled after neurotransmitter release. It has been assumed that these vesicles must cluster at the active zones of the presynaptic nerve terminal membrane so that they can rapidly release their contents in response to electrical stimulation. In their Perspective, Holt and Jahn reveal that rapidly recycled synaptic vesicles are, in fact, randomly distributed throughout the nerve terminal (Rizzoli and Betz), suggesting that they must carry some type of marker that distinguishes them from the rest of the vesicle pool.

The authors are in the Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany. E-mail: rjahn{at}gwdg.de

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synaptic vesicles in rat hippocampal boutons recycle to different pools in a use-dependent fashion.
P. Vanden Berghe and J. Klingauf (2006)
J. Physiol. 572, 707-720
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