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Science 26 March 2004:
Vol. 303. no. 5666, pp. 1983 - 1984
DOI: 10.1126/science.1096414
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Perspectives

NEUROSCIENCE:
Genetic Control of Cortical Convolutions

Pasko Rakic

Development of the highly convoluted human cerebral cortex depends on the orchestrated migration of millions of cortical neurons from the brain's ventricular and subventricular zones. In a Perspective, Rakic discusses the identification of a mutation in an orphan G protein-coupled receptor that results in a congenital malformation in which overproduction of cortical neurons results in the appearance of an enlarged number of cortical convolutions (Piao et al.).

The author is in the Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA. E-mail: pasko.rakic{at}yale.edu

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