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The family of Toll-like receptors have garnered much interest because of their ability to detect bacterial and viral molecules and to activate the innate immune response. In his Perspective, O'Neill introduces a trio of papers (Zhang et al., Heil et al., and Diebold et al.) that provide new information about how Toll-like receptors activate innate immunity.
The author is in the Department of Biochemistry, Trinity College, Dublin, Ireland. E-mail: laoneill{at}tcd.ie
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In Science Magazine
REPORTS
Sandra S. Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi, Shizuo Akira, and Caetano Reis e Sousa (5 March 2004) Science303 (5663), 1529.
[DOI: 10.1126/science.1093616] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Florian Heil, Hiroaki Hemmi, Hubertus Hochrein, Franziska Ampenberger, Carsten Kirschning, Shizuo Akira, Grayson Lipford, Hermann Wagner, and Stefan Bauer (5 March 2004) Science303 (5663), 1526.
[DOI: 10.1126/science.1093620] |Abstract »|Full Text »|PDF »|Supporting Online Material »
REPORTS
Dekai Zhang, Guolong Zhang, Matthew S. Hayden, Matthew B. Greenblatt, Crystal Bussey, Richard A. Flavell, and Sankar Ghosh (5 March 2004) Science303 (5663), 1522.
[DOI: 10.1126/science.1094351] |Abstract »|Full Text »|PDF »|Supporting Online Material »
HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-{alpha}.
A. W. Hardy, D. R. Graham, G. M. Shearer, and J.-P. Herbeuval (2007)
PNAS
104, 17453-17458
|Abstract »|Full Text »|PDF »
Infectious RNA Isolated from the Spinal Cords of Mice Chronically Infected with Theiler's Murine Encephalomyelitis Virus.
J. E. Libbey, I. Tsunoda, J. L. Whitton, and R. S. Fujinami (2007)
J. Virol.
81, 3009-3011
|Abstract »|Full Text »|PDF »
The Functional Effects of Physical Interactions among Toll-like Receptors 7, 8, and 9.
J. Wang, Y. Shao, T. A. Bennett, R. A. Shankar, P. D. Wightman, and L. G. Reddy (2006)
J. Biol. Chem.
281, 37427-37434
|Abstract »|Full Text »|PDF »
TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation.
C. Qian, X. Jiang, H. An, Y. Yu, Z. Guo, S. Liu, H. Xu, and X. Cao (2006)
Blood
108, 2307-2315
|Abstract »|Full Text »|PDF »
Antibodies against human Toll-like receptors (TLRs): TLR distribution and localization in human dendritic cells.
T. Seya, K. Funami, M. Taniguchi, and M. Matsumoto (2005)
Innate Immunity
11, 369-374
|Abstract »|PDF »
Selective Recognition of Synthetic Lysine and meso-Diaminopimelic Acid-type Peptidoglycan Fragments by Human Peptidoglycan Recognition Proteins I{alpha} and S.
S. Kumar, A. Roychowdhury, B. Ember, Q. Wang, R. Guan, R. A. Mariuzza, and G.-J. Boons (2005)
J. Biol. Chem.
280, 37005-37012
|Abstract »|Full Text »|PDF »
Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-{kappa}B.
M. Loiarro, C. Sette, G. Gallo, A. Ciacci, N. Fanto, D. Mastroianni, P. Carminati, and V. Ruggiero (2005)
J. Biol. Chem.
280, 15809-15814
|Abstract »|Full Text »|PDF »
Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I.
R. Sumpter Jr., Y.-M. Loo, E. Foy, K. Li, M. Yoneyama, T. Fujita, S. M. Lemon, and M. Gale Jr. (2005)
J. Virol.
79, 2689-2699
|Abstract »|Full Text »|PDF »
Unraveling the Molecular Details Involved in the Intimate Link between the Immune and Neuroendocrine Systems.
N. P. Turrin and S. Rivest (2004)
Experimental Biology and Medicine
229, 996-1006
|Abstract »|Full Text »|PDF »
Newly Discovered Molecule Important in the Pathogenesis of UTIs.
(2004)
Journal Watch (General)
2004, 3
|Full Text »
