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Science 5 March 2004:
Vol. 303. no. 5663, pp. 1454 - 1456
DOI: 10.1126/science.303.5663.1454
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News Focus

CELL BIOLOGY:
How Cells Endure Low Oxygen

Jean Marx

As researchers unravel the biochemical system by which cells register and respond to hypoxia, they're coming up with potential new strategies for treating cancer, heart attack, and stroke.

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A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia.
M. Nangaku, Y. Izuhara, S. Takizawa, T. Yamashita, Y. Fujii-Kuriyama, O. Ohneda, M. Yamamoto, C. van Ypersele de Strihou, N. Hirayama, and T. Miyata (2007)
Arterioscler Thromb Vasc Biol 27, 2548-2554
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Cell Type-specific Effect of Hypoxia and Platelet-derived Growth Factor-BB on Extracellular Matrix Turnover and Its Consequences for Lung Remodeling.
G. Karakiulakis, E. Papakonstantinou, A. J. Aletras, M. Tamm, and M. Roth (2007)
J. Biol. Chem. 282, 908-915
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Chronic Hypoxia and Tubulointerstitial Injury: A Final Common Pathway to End-Stage Renal Failure.
M. Nangaku (2006)
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Signal Pathway of Hypoxia-Inducible Factor-1{alpha} Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells.
S. J. Kwon, J. J. Song, and Y. J. Lee (2005)
Clin. Cancer Res. 11, 7607-7613
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Transdermal Sustained-Delivery Oxygen Improves Epithelial Healing in a Rabbit Ear Wound Model.
H. K. Said, J. Hijjawi, N. Roy, J. Mogford, and T. Mustoe (2005)
Arch Surg 140, 998-1004
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Gene manipulation and improvement of athletic performances: new strategies in blood doping.
G Lippi and G C Guidi (2004)
Br. J. Sports Med. 38, 641
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Science. ISSN 0036-8075 (print), 1095-9203 (online)