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Science 20 February 2004:
Vol. 303. no. 5661, pp. 1149 - 1150
DOI: 10.1126/science.1095519

Perspectives

BIOMEDICINE:
Will the Real Cholesterol Transporter Please Stand Up

Eric L. Klett and Shailesh B. Patel

The link between high plasma cholesterol and heart disease has spurred interest in understanding cholesterol homeostasis. In their Perspective, Klett and Patel shed light on new research (Altmann et al.) that identifies a putative intestinal cholesterol transport protein, a key component of the dietary cholesterol absorption pathway.


The authors are in the Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA. E-mail: patelsb{at}musc.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
M. Garcia-Calvo, J. Lisnock, H. G. Bull, B. E. Hawes, D. A. Burnett, M. P. Braun, J. H. Crona, H. R. Davis Jr., D. C. Dean, P. A. Detmers, et al. (2005)
PNAS 102, 8132-8137
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Aminopeptidase N (CD13) Is a Molecular Target of the Cholesterol Absorption Inhibitor Ezetimibe in the Enterocyte Brush Border Membrane.
W. Kramer, F. Girbig, D. Corsiero, A. Pfenninger, W. Frick, G. Jahne, M. Rhein, W. Wendler, F. Lottspeich, E. O. Hochleitner, et al. (2005)
J. Biol. Chem. 280, 1306-1320
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Interaction of cholesterol with sphingosine: physicochemical characterization and impact on intestinal absorption.
N. Garmy, N. Taieb, N. Yahi, and J. Fantini (2005)
J. Lipid Res. 46, 36-45
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The ABCs of vitamin E and {beta}-carotene absorption.
M. G Traber (2004)
Am. J. Clinical Nutrition 80, 3-4
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