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Science 20 February 2004:
Vol. 303. no. 5661, pp. 1148 - 1149
DOI: 10.1126/science.1095356
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Perspectives

MOLECULAR BIOLOGY:
Filling Gaps in Genome Organization

Artyom A. Alekseyenko and Mitzi I. Kuroda

Dosage compensation is a mechanism that redresses the X chromosome imbalance between males and females by reducing gene expression from the whole X chromosome. In their Perspective, Alekseyenko and Kuroda discuss new research in the nematode (Csankovszki et al.) that follows the movements of the protein complex responsible for X chromosome repression in this organism.

The authors are at the Howard Hughes Medical Institute, Harvard-Partners Center for Genetics & Genomics, Harvard Medical School, Boston, MA 02115, USA. E-mail: aalekseyenko{at}rics.bwh.harvard.edu, mkuroda{at}genetics.med.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering.
W.-M. Boon, T. Beissbarth, L. Hyde, G. Smyth, J. Gunnersen, D. A. Denton, H. Scott, and S.-S. Tan (2004)
PNAS 101, 14972-14977
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Science. ISSN 0036-8075 (print), 1095-9203 (online)