Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 February 2004:
Vol. 303. no. 5660, pp. 944 - 946
DOI: 10.1126/science.303.5660.944
Prev | Table of Contents | Next

News Focus

MEDICINE:
Caution Urged on SARS Vaccines

Eliot Marshall and Martin Enserink

WASHINGTON, D.C., AND ROTTERDAM--A year of frenzied research has produced several candidate vaccines for severe acute respiratory syndrome. The first question is, how safe are they? And second, how will they be tested?

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intranasal Vaccination of Recombinant Adeno-Associated Virus Encoding Receptor-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Spike Protein Induces Strong Mucosal Immune Responses and Provides Long-Term Protection against SARS-CoV Infection.
L. Du, G. Zhao, Y. Lin, H. Sui, C. Chan, S. Ma, Y. He, S. Jiang, C. Wu, K.-Y. Yuen, et al. (2008)
J. Immunol. 180, 948-956
   Abstract »    Full Text »    PDF »
Antigenic and Immunogenic Characterization of Recombinant Baculovirus-Expressed Severe Acute Respiratory Syndrome Coronavirus Spike Protein: Implication for Vaccine Design..
Y. He, J. Li, S. Heck, S. Lustigman, and S. Jiang (2006)
J. Virol. 80, 5757-5767
   Abstract »    Full Text »    PDF »
Cross-Neutralization of Human and Palm Civet Severe Acute Respiratory Syndrome Coronaviruses by Antibodies Targeting the Receptor-Binding Domain of Spike Protein.
Y. He, J. Li, W. Li, S. Lustigman, M. Farzan, and S. Jiang (2006)
J. Immunol. 176, 6085-6092
   Abstract »    Full Text »    PDF »
Modulation of the Immune Response to the Severe Acute Respiratory Syndrome Spike Glycoprotein by Gene-Based and Inactivated Virus Immunization.
W.-p. Kong, L. Xu, K. Stadler, J. B. Ulmer, S. Abrignani, R. Rappuoli, and G. J. Nabel (2005)
J. Virol. 79, 13915-13923
   Abstract »    Full Text »    PDF »
Identification of Immunodominant Epitopes on the Membrane Protein of the Severe Acute Respiratory Syndrome-Associated Coronavirus.
Y. He, Y. Zhou, P. Siddiqui, J. Niu, and S. Jiang (2005)
J. Clin. Microbiol. 43, 3718-3726
   Abstract »    Full Text »    PDF »
Response of Memory CD8+ T Cells to Severe Acute Respiratory Syndrome (SARS) Coronavirus in Recovered SARS Patients and Healthy Individuals.
H. Chen, J. Hou, X. Jiang, S. Ma, M. Meng, B. Wang, M. Zhang, M. Zhang, X. Tang, F. Zhang, et al. (2005)
J. Immunol. 175, 591-598
   Abstract »    Full Text »    PDF »
Severe acute respiratory syndrome (SARS) S protein production in plants: Development of recombinant vaccine.
N. Pogrebnyak, M. Golovkin, V. Andrianov, S. Spitsin, Y. Smirnov, R. Egolf, and H. Koprowski (2005)
PNAS 102, 9062-9067
   Abstract »    Full Text »    PDF »
Receptor-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Contains Multiple Conformation-Dependent Epitopes that Induce Highly Potent Neutralizing Antibodies.
Y. He, H. Lu, P. Siddiqui, Y. Zhou, and S. Jiang (2005)
J. Immunol. 174, 4908-4915
   Abstract »    Full Text »    PDF »
B-Cell Responses in Patients Who Have Recovered from Severe Acute Respiratory Syndrome Target a Dominant Site in the S2 Domain of the Surface Spike Glycoprotein.
X. Zhong, H. Yang, Z.-F. Guo, W.-Y. F. Sin, W. Chen, J. Xu, L. Fu, J. Wu, C.-K. G. Mak, C.-S. S. Cheng, et al. (2005)
J. Virol. 79, 3401-3408
   Abstract »    Full Text »    PDF »
Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets.
H. Weingartl, M. Czub, S. Czub, J. Neufeld, P. Marszal, J. Gren, G. Smith, S. Jones, R. Proulx, Y. Deschambault, et al. (2004)
J. Virol. 78, 12672-12676
   Abstract »    Full Text »    PDF »
Mapping of Antigenic Sites on the Nucleocapsid Protein of the Severe Acute Respiratory Syndrome Coronavirus.
Y. He, Y. Zhou, H. Wu, Z. Kou, S. Liu, and S. Jiang (2004)
J. Clin. Microbiol. 42, 5309-5314
   Abstract »    Full Text »    PDF »
Identification of Immunodominant Sites on the Spike Protein of Severe Acute Respiratory Syndrome (SARS) Coronavirus: Implication for Developing SARS Diagnostics and Vaccines.
Y. He, Y. Zhou, H. Wu, B. Luo, J. Chen, W. Li, and S. Jiang (2004)
J. Immunol. 173, 4050-4057
   Abstract »    Full Text »    PDF »
Glycan arrays lead to the discovery of autoimmunogenic activity of SARS-CoV.
D. Wang and J. Lu (2004)
Physiol Genomics 18, 245-248
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)