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Science 9 January 2004:
Vol. 303. no. 5655, pp. 182 - 184
DOI: 10.1126/science.1093514
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Perspectives

MOLECULAR BIOLOGY:
Ring Around the Retroelement

Philip S. Perlman and Jef D. Boeke

Molecular biologists have long been intrigued by mobile DNA elements in the genome called retrotransposons and how they replicate and become inserted at new chromosomal sites. New insights into how branching and debranching of retrotransposon transcripts may contribute to this process (Cheng and Menees) are discussed by Perlman and Boeke in their Perspective.

P. S. Perlman is in the Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. E-mail: philip.perlman{at}utsouthwestern.edu J. D. Boeke is in the Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. E-mail: jboeke{at}jhmi.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ty1 reverse transcriptase does not read through the proposed 2',5'-branched retrotransposition intermediate in vitro.
E. D. Pratico and S. K. Silverman (2007)
RNA 13, 1528-1536
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A deoxyribozyme that synthesizes 2',5'-branched RNA with any branch-site nucleotide.
E. D. Pratico, Y. Wang, and S. K. Silverman (2005)
Nucleic Acids Res. 33, 3503-3512
   Abstract »    Full Text »    PDF »
An evaluation of detection methods for large lariat RNAs.
C. E. COOMBES and J. D. BOEKE (2005)
RNA 11, 323-331
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Science. ISSN 0036-8075 (print), 1095-9203 (online)