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Science 19 December 2003:
Vol. 302. no. 5653, pp. 2077 - 2078
DOI: 10.1126/science.1093203
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Perspectives

DEVELOPMENTAL BIOLOGY:
Tubulogenesis CLICs into Place

Sarah M. Paul and Greg J. Beitel

Organs such as the kidney and vascular system have tubes as their functional units. Vital though such tubes are, little is known about how they are formed during embryonic development. In their Perspective, Paul and Beitel discuss new work in the worm (Berry et al.) demonstrating that an intracellular chloride channel protein called EXC-4 is required for tube formation.

The authors are in the Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA. E-mail: beitel{at}northwestern.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)