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Science 19 December 2003:
Vol. 302. no. 5653, p. 2029
DOI: 10.1126/science.302.5653.2029n
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This Week in Science
Resistance to infection with Gram-positive bacteria in Drosophila depends on the induction of antimicrobial peptides by the Toll pattern recognition pathway. Toll receptor activation follows the proteolytic cleavage of its putative ligand precursor, Spätzle, through mechanisms that are incompletely defined. Gobert et al. (p. 2126) used a genetic mutant screen to identify the Gram-negative binding protein 1 (GNBP1) as critical in the survival of flies after infection with Gram-positive bacteria, but not after infection with fungi or Gram-negative bacteria. A similar role is already established for peptidoglycan recognition protein SA. The two proteins may cooperate in the activation of the proteolytic cascade that activates Spätzle. The pattern sensing response of invertebrates is thus more complex than has been appreciated.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
