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Science 12 December 2003:
Vol. 302. no. 5652, pp. 1900 - 1902
DOI: 10.1126/science.1092873
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Perspectives

MICROBIOLOGY:
Chemical Warfare and Mycobacterial Defense

Jean Pieters and Hidde Ploegh

Part of the reason that Mycobacterium tuberculosis is such a successful pathogen is that it has learned how to survive inside the lysosomes of host macrophages. In their Perspective, Pieters and Ploegh describe one reason for the success of this microbe: Its proteasomes are able to protect mycobacterial proteins against attack by nitric oxide and its derivatives, which are produced inside the macrophage lysosomes (Darwin et al.).

J. Pieters is at the Biozentrum, University of Basel, Basel CH 4056, Switzerland. H. Ploegh is in the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. E-mail: jean.pieters{at}unibas.ch

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Science. ISSN 0036-8075 (print), 1095-9203 (online)