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The transcription factor SREBP-2 is a crucial component in cholesterol metabolism, switching on genes that regulate the synthesis and uptake of cholesterol. To activate these genes, SREBP-2 must be transported from the cytoplasm into the nucleus. In his Perspective, Stewart discusses an analysis of the crystal structure of SREBP-2 bound to its nuclear transport protein, importin-, which sheds new light on SREBP-2 nuclear transport (Lee et al.).
The author is at the MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK. E-mail: ms{at}mrc-lmb.cam.ac.uk
Defective Calmodulin-Mediated Nuclear Transport of the Sex-Determining Region of the Y Chromosome (SRY) in XY Sex Reversal.
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|Abstract »|Full Text »|PDF »
Domain Architectures and Characterization of an RNA-binding Protein, TLS.
Y. Iko, T. S. Kodama, N. Kasai, T. Oyama, E. H. Morita, T. Muto, M. Okumura, R. Fujii, T. Takumi, S.-i. Tate, et al. (2004)
J. Biol. Chem.
279, 44834-44840
|Abstract »|Full Text »|PDF »
, which sheds new light on SREBP-2 nuclear transport (
