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Science 7 November 2003:
Vol. 302. no. 5647, pp. 997 - 999
DOI: 10.1126/science.1092271
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Perspectives

EVOLUTION:
Heirlooms in the Attic

Mark Johnston and Gary D. Stormo

As the human genome was being sequenced, many people suggested just sequencing protein-coding regions because the rest of the genome is "junk" DNA. As Johnston and Stormo explain in their Perspective, thankfully those who advocated sequencing the entire genome did us all a big service. It turns out that a surprising proportion of the so-called junk DNA is highly conserved (Dermitzakis et al.), suggesting that even though it is noncoding DNA, it does have important functions that have yet to be elucidated.

The authors are in the Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. E-mail: mj{at}wustl.edu

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