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We depend on the efficiency of our adaptive immune system to combat pathogen invaders. Part of this protective response includes development of CD4 and CD8 effector T cells. As Hatton and Weaver discuss in their Perspective, key transcription factors regulating CD4 effector T cell development have been identified, whereas those governing the development of CD8 effectors have not. Hatton and Weaver describe new work showing that cooperation between two T-box transcription factors, T-bet and Eomesodermin, instigates the CD8 effector program (Pearce et al.).
The authors are in the Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Protective Immunity to Genital Herpes Simpex Virus Type 2 Infection Is Mediated by T-bet.
A. Svensson, I. Nordstrom, J.-B. Sun, and K. Eriksson (2005)
J. Immunol.
174, 6266-6273
|Abstract »|Full Text »|PDF »
TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids.
K. G. Tantisira, E. S. Hwang, B. A. Raby, E. S. Silverman, S. L. Lake, B. G. Richter, S. L. Peng, J. M. Drazen, L. H. Glimcher, and S. T. Weiss (2004)
PNAS
101, 18099-18104
|Abstract »|Full Text »|PDF »
Activation of Signaling Lymphocytic Activation Molecule Triggers a Signaling Cascade That Enhances Th1 Responses in Human Intracellular Infection.
M. F. Quiroga, G. J. Martinez, V. Pasquinelli, M. A. Costas, M. M. Bracco, A. Malbran, L. M. Olivares, P. A. Sieling, and V. E. Garcia (2004)
J. Immunol.
173, 4120-4129
|Abstract »|Full Text »|PDF »
