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Science 26 September 2003:
Vol. 301. no. 5641, pp. 1854 - 1855
DOI: 10.1126/science.1090531
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Perspectives

GENOMICS:
A Dog's Breakfast?

Stephen J. O'Brien and William J. Murphy

The genomes of human, mouse, and rat have been sequenced. Now, as O'Brien and Murphy announce in their Perspective, the genome sequence derby is heating up with the addition of dog to the list (Kirkness et al.). As they explain, even though the coverage of the dog genome (1.5x) is lower than that of mouse (8x), there are many valuable insights to be gained from comparing the sequence of dog with those of mouse and human.

The authors are at the Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Artifacts of the 1.9x Feline Genome Assembly Derived from the Feline-Specific Satellite Sequence.
J. U. Pontius and S. J. O'Brien (2009)
J. Hered. 100, S14-S18
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Initial sequence and comparative analysis of the cat genome.
J. U. Pontius, J. C. Mullikin, D. R. Smith, Agencourt Sequencing Team, K. Lindblad-Toh, S. Gnerre, M. Clamp, J. Chang, R. Stephens, B. Neelam, et al. (2007)
Genome Res. 17, 1675-1689
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Disparity, adaptation, exaptation, bookkeeping, and contingency at the genome level.
J. Brosius (2005)
Paleobiology 31, 1-16
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Functional Genomics of Lung Disease.
J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. (2004)
Am. J. Respir. Cell Mol. Biol. 31, S1-S81
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Building Comparative Maps Using 1.5x Sequence Coverage: Human Chromosome 1p and the Canine Genome.
R. GUYON, E.F. KIRKNESS, T.D. LORENTZEN, C. HITTE, K.E. COMSTOCK, P. QUIGNON, T. DERRIEN, C. ANDRE, C.M. FRASER, F. GALIBERT, et al. (2003)
Cold Spring Harb Symp Quant Biol 68, 171-178
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