Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 September 2003:
Vol. 301. no. 5640, pp. 1682 - 1685
DOI: 10.1126/science.1090462
Prev | Table of Contents | Next

Perspectives

NEUROSCIENCE:
From Molecules to Memory in the Cerebellum

David J. Linden

Neuroscientists have long sought to elucidate the molecular underpinnings of the memories needed to learn, for example, a motor task. In his Perspective, Linden discusses new work (Koekkoek et al.) suggesting that long-term depression in Purkinje cells mediated by protein kinase C signaling is responsible for motor memory in a task called associative eyelid conditioning.

The author is in the Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. E-mail: dlinden{at}jhmi.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuronal and Intestinal Protein Kinase D Isoforms Mediate Na+ (Salt Taste)-Induced Learning.
Y. Fu, M. Ren, H. Feng, L. Chen, Z. F. Altun, and C. S. Rubin (2009)
Science Signaling 2, ra42
   Abstract »    Full Text »    PDF »
Isoform specificity of protein kinase Cs in synaptic plasticity.
W. S. Sossin (2007)
Learn. Mem. 14, 236-246
   Abstract »    Full Text »    PDF »
Isoform Specificity of PKC Translocation in Living Aplysia Sensory Neurons and a Role for Ca2+-Dependent PKC APL I in the Induction of Intermediate-Term Facilitation..
Y. Zhao, K. Leal, C. Abi-Farah, K. C. Martin, W. S. Sossin, and M. Klein (2006)
J. Neurosci. 26, 8847-8856
   Abstract »    Full Text »    PDF »
An NMDA Receptor/Nitric Oxide Cascade Is Involved in Cerebellar LTD But Is Not Localized to the Parallel Fiber Terminal.
J. H. Shin and D. J. Linden (2005)
J Neurophysiol 94, 4281-4289
   Abstract »    Full Text »    PDF »
Timing of Conditioned Eyeblink Responses Is Impaired in Cerebellar Patients.
M. Gerwig, K. Hajjar, A. Dimitrova, M. Maschke, F. P. Kolb, M. Frings, A. F. Thilmann, M. Forsting, H. C. Diener, and D. Timmann (2005)
J. Neurosci. 25, 3919-3931
   Abstract »    Full Text »    PDF »
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.
M. Sausbier, H. Hu, C. Arntz, S. Feil, S. Kamm, H. Adelsberger, U. Sausbier, C. A. Sailer, R. Feil, F. Hofmann, et al. (2004)
PNAS 101, 9474-9478
   Abstract »    Full Text »    PDF »
Comment on "Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses".
K. M. Christian, A. M. Poulos, D. G. Lavond, and R. F. Thompson (2004)
Science 304, 211b
   Full Text »    PDF »
Temporal Properties of Cerebellar-Dependent Memory Consolidation.
S. F. Cooke, P. J. E. Attwell, and C. H. Yeo (2004)
J. Neurosci. 24, 2934-2941
   Abstract »    Full Text »    PDF »
Reversing cerebellar long-term depression.
V. Lev-Ram, S. B. Mehta, D. Kleinfeld, and R. Y. Tsien (2003)
PNAS 100, 15989-15993
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)