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CELL SIGNALING: β-Arrestin--Not Just for G Protein-Coupled Receptors
Allen Spiegel
The -arrestin adaptor proteins are known to mediate the endocytosis of G protein-coupled receptors. In this way, they down-regulate the activated receptors ensuring that they are degraded or recycled within the cell. As Spiegel explains in his Perspective, it now turns out that -arrestins are also important for the endocytosis and down-regulation of a variety of other receptors including Frizzled 4 and TGF--receptors, II and III (Chen et al., Chen et al.).
The author is at the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. E-mail: spiegela{at}extra.niddk.nih.gov
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Wei Chen, Kellye C. Kirkbride, Tam How, Christopher D. Nelson, Jinyao Mo, Joshua P. Frederick, Xiao-Fan Wang, Robert J. Lefkowitz, and Gerard C. Blobe (5 September 2003) Science301 (5638), 1394.
[DOI: 10.1126/science.1083195] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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-arrestin adaptor proteins are known to mediate the endocytosis of G protein-coupled receptors. In this way, they down-regulate the activated receptors ensuring that they are degraded or recycled within the cell. As 
