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T cells of the adaptive immune system detect foreign pathogens by recognizing pathogen-derived peptides in a complex with MHC class I molecules presented on the surface of infected cells. In a Perspective, Yewdell discusses progress in understanding how cells generate peptides from cellular and viral proteins and the wily ways in which the Epstein Barr virus conceals its peptide products from the host immune system (Schwab et al., Yin et al.).
The author is at the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA. E-mail: jyewdell{at}nih.gov
AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape.
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|Abstract »|Full Text »|PDF »
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Int. Immunol.
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|Abstract »|Full Text »|PDF »
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J. Exp. Med.
199, 1053-1063
|Abstract »|Full Text »|PDF »
