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Science 5 September 2003:
Vol. 301. no. 5638, pp. 1308 - 1310
DOI: 10.1126/science.301.5638.1308
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News Focus

CANCER RESEARCH:
Mutant Stem Cells May Seed Cancer

Jean Marx

Some cancers are sustained by a small minority of cells; their resemblance to normal stem cells might explain why many cancers are so hard to eradicate, and it has researchers rethinking cancer treatments.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor Angiogenesis.
R. S. Kerbel (2008)
N. Engl. J. Med. 358, 2039-2049
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Angiogenesis-independent tumor growth mediated by stem-like cancer cells.
P. O. Sakariassen, L. Prestegarden, J. Wang, K.-O. Skaftnesmo, R. Mahesparan, C. Molthoff, P. Sminia, E. Sundlisaeter, A. Misra, B. B. Tysnes, et al. (2006)
PNAS 103, 16466-16471
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Primary Glioblastomas Express Mesenchymal Stem-Like Properties.
C.-L. Tso, P. Shintaku, J. Chen, Q. Liu, J. Liu, Z. Chen, K. Yoshimoto, P. S. Mischel, T. F. Cloughesy, L. M. Liau, et al. (2006)
Mol. Cancer Res. 4, 607-619
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Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties.
D. Ponti, A. Costa, N. Zaffaroni, G. Pratesi, G. Petrangolini, D. Coradini, S. Pilotti, M. A. Pierotti, and M. G. Daidone (2005)
Cancer Res. 65, 5506-5511
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Spontaneous Human Adult Stem Cell Transformation.
D. Rubio, J. Garcia-Castro, M. C. Martin, R. de la Fuente, J. C. Cigudosa, A. C. Lloyd, and A. Bernad (2005)
Cancer Res. 65, 3035-3039
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Tumorigenic Heterogeneity in Cancer Stem Cells Evolved from Long-term Cultures of Telomerase-Immortalized Human Mesenchymal Stem Cells.
J. S. Burns, B. M. Abdallah, P. Guldberg, J. Rygaard, H. D. Schroder, and M. Kassem (2005)
Cancer Res. 65, 3126-3135
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Will cancer stem cells provide new therapeutic targets?.
F. Behbod and J. M. Rosen (2005)
Carcinogenesis 26, 703-711
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From the Library.
(2003)
Br J Ophthalmol 87, 1436
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