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Science 29 August 2003:
Vol. 301. no. 5637, p. 1165
DOI: 10.1126/science.301.5637.1165
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News of the Week

LONGEVITY RESEARCH:
In Vino Vitalis? Compounds Activate Life-Extending Genes

Stephen S. Hall

Several naturally occurring small molecules extend the life of yeast cells by approximately 70% and offer some protection to cultured human cells exposed to radiation, researchers reported online in Nature on 24 August. The molecules belong to a family of chemicals known as polyphenols, some of which are prominent components of grapes, red wine, olive oil, and other foods.

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Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases.
K. Zhao, R. Harshaw, X. Chai, and R. Marmorstein (2004)
PNAS 101, 8563-8568
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Molecule in Red Wine Extends Lifespan of Yeast.
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Journal Watch Cardiology 2003, 3
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Molecule in Red Wine Extends Lifespan of Yeast.
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Journal Watch (General) 2003, 4
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Science. ISSN 0036-8075 (print), 1095-9203 (online)