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Science 15 August 2003:
Vol. 301. no. 5635, pp. 923 - 925
DOI: 10.1126/science.1088965
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Perspectives

VIROLOGY:
Weapons of Mutational Destruction

Vineet N. KewalRamani and John M. Coffin

The viral accessory protein Vif is required for the production of infectious virions by cells that do not normally permit viral replication to take place. In their Perspective, KewalRamani and Coffin discuss an exciting cluster of recent papers that identify a new viral mutagenic factor called APOBEC3G, which counteracts Vif's ability to enable viral replication in nonpermissive cells.

V. N. KewalRamani is in the HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA. E-mail: vineet{at}ncifcrf.gov J. M. Coffin is in the Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA. E-mail: john.coffin{at}tufts.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H.
J. Kock and H. E. Blum (2008)
J. Gen. Virol. 89, 1184-1191
   Abstract »    Full Text »    PDF »
Cytidine deamination induced HIV-1 drug resistance.
L. C. F. Mulder, A. Harari, and V. Simon (2008)
PNAS 105, 5501-5506
   Abstract »    Full Text »    PDF »
Biochemical Activities of Highly Purified, Catalytically Active Human APOBEC3G: Correlation with Antiviral Effect..
Y. Iwatani, H. Takeuchi, K. Strebel, and J. G. Levin (2006)
J. Virol. 80, 5992-6002
   Abstract »    Full Text »    PDF »
Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G".
C. Rosler, J. Kock, M. H. Malim, H. E. Blum, and F. von Weizsacker (2004)
Science 305, 1403a
   Full Text »    PDF »
From the Cover: In defense of the cell: TRIM5{alpha} interception of mammalian retroviruses.
K. Lee and V. N. KewalRamani (2004)
PNAS 101, 10496-10497
   Full Text »    PDF »
Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication.
Y.-H. Zheng, D. Irwin, T. Kurosu, K. Tokunaga, T. Sata, and B. M. Peterlin (2004)
J. Virol. 78, 6073-6076
   Abstract »    Full Text »    PDF »
APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase.
R. Suspene, P. Sommer, M. Henry, S. Ferris, D. Guetard, S. Pochet, A. Chester, N. Navaratnam, S. Wain-Hobson, and J.-P. Vartanian (2004)
Nucleic Acids Res. 32, 2421-2429
   Abstract »    Full Text »    PDF »
Inhibition of Hepatitis B Virus Replication by APOBEC3G.
P. Turelli, B. Mangeat, S. Jost, S. Vianin, and D. Trono (2004)
Science 303, 1829
   Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)