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Also see the archival list of Science's Compass: Enhanced Perspectives
STRUCTURAL BIOLOGY: Enhanced: Breaching the Barrier
Kaspar P. Locher, Randal B. Bass, Douglas C. Rees
There are a huge number of membrane transporter proteins that transport molecules across the impermeable barrier presented by cellular membranes. In their Perspective, Locher et al. discuss a double tour de force (Abramson et al., Huang et al.), which provide structural determinations of two bacterial transporters, LacY and GlpT, and insights into how they work.
K. P. Locher is at the Institut für Molekularbiologie und Biophysik, Eidgenössische Technische Hochschule Zürich, Zürich CH-8093, Switzerland. R. B. Bass and D. C. Rees are at the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. E-mail: dcrees{at}caltech.edu
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RESEARCH ARTICLES
Jeff Abramson, Irina Smirnova, Vladimir Kasho, Gillian Verner, H. Ronald Kaback, and So Iwata (1 August 2003) Science301 (5633), 610.
[DOI: 10.1126/science.1088196] |Abstract »|Full Text »|PDF »|Supporting Online Material »
