MEDICINE: Drug Deals Diabetes a One-Two Punch

doi:10.1126/science.301.5631.290

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Science 18 July 2003:
Vol. 301. no. 5631, p. 290
DOI: 10.1126/science.301.5631.290

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MEDICINE:
Drug Deals Diabetes a One-Two Punch

Jennifer Couzin

An enzyme called glucokinase regulates two key functions that fail in diabetics: secretion of insulin by the pancreas and production of glucose by the liver. On page 370, molecular pharmacologists describe how a single oral dose of a glucokinase activator caused blood sugar levels in diabetic mice to plummet by half.

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REPORTS Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy: Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett, Nancy-Ellen Haynes, Fred T. Bizzarro, John W. Coffey, Kevin R. Guertin, Darryl W. Hilliard, Robert F. Kester, Paige E. Mahaney, Linda Marcus, Lida Qi, Cheryl L. Spence, John Tengi, Mark A. Magnuson, Chang An Chu, Mark T. Dvorozniak, Franz M. Matschinsky, and Joseph F. Grippo (18 July 2003)
Science 301 (5631), 370. [DOI: 10.1126/science.1084073]
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