Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
STRUCTURAL BIOLOGY: A Ménage à Trois in Two Configurations
J. Evan Sadler
The interaction of thrombin with the GpIb-IX-V complex on the surface of platelets is crucial for the formation of blood clots following vascular injury. In a Perspective, Sadler discusses two new crystallographic studies (Celikel et al., Dumas et al.) that shed new but perhaps conflicting light on this vital interaction.
The author is at the Howard Hughes Medical Institute, Department of Medicine and Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO 63110, USA. E-mail: esadler{at}im.wustl.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Reha Celikel, Richard A. McClintock, James R. Roberts, G. Loredana Mendolicchio, Jerry Ware, Kottayil I. Varughese, and Zaverio M. Ruggeri (11 July 2003) Science301 (5630), 218.
[DOI: 10.1126/science.1084183] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Thrombin Mutant W215A/E217A Acts as a Platelet GPIb Antagonist.
M. A. Berny, T. C. White, E. I. Tucker, L. A. Bush-Pelc, E. Di Cera, A. Gruber, and O. J.T. McCarty (2008)
Arterioscler. Thromb. Vasc. Biol.
28, 329-334
|Abstract »|Full Text »|PDF »
Detection and Purification of Tyrosine-sulfated Proteins Using a Novel Anti-sulfotyrosine Monoclonal Antibody.
A. J. Hoffhines, E. Damoc, K. G. Bridges, J. A. Leary, and K. L. Moore (2006)
J. Biol. Chem.
281, 37877-37887
|Abstract »|Full Text »|PDF »
Glycoprotein Ib{alpha}-Mediated Platelet Adhesion and Aggregation to Immobilized Thrombin Under Conditions of Flow.
C. Weeterings, J. Adelmeijer, T. Myles, P. G. de Groot, and T. Lisman (2006)
Arterioscler. Thromb. Vasc. Biol.
26, 670-675
|Abstract »|Full Text »|PDF »
Directing thrombin.
D. A. Lane, H. Philippou, and J. A. Huntington (2005)
Blood
106, 2605-2612
|Abstract »|Full Text »|PDF »
Effects of Thrombin on Interactions Between {beta}3-Integrins and Extracellular Matrix in Platelets and Vascular Cells.
G.A. Stouffer and S.S. Smyth (2003)
Arterioscler. Thromb. Vasc. Biol.
23, 1971-1978
|Abstract »|Full Text »|PDF »
