Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 July 2003:
Vol. 301. no. 5630, pp. 177 - 179
DOI: 10.1126/science.1087734
Prev | Table of Contents | Next

Perspectives

STRUCTURAL BIOLOGY:
A Ménage à Trois in Two Configurations

J. Evan Sadler

The interaction of thrombin with the GpIb-IX-V complex on the surface of platelets is crucial for the formation of blood clots following vascular injury. In a Perspective, Sadler discusses two new crystallographic studies (Celikel et al., Dumas et al.) that shed new but perhaps conflicting light on this vital interaction.

The author is at the Howard Hughes Medical Institute, Department of Medicine and Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO 63110, USA. E-mail: esadler{at}im.wustl.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thrombin Mutant W215A/E217A Acts as a Platelet GPIb Antagonist.
M. A. Berny, T. C. White, E. I. Tucker, L. A. Bush-Pelc, E. Di Cera, A. Gruber, and O. J.T. McCarty (2008)
Arterioscler Thromb Vasc Biol 28, 329-334
   Abstract »    Full Text »    PDF »
Detection and Purification of Tyrosine-sulfated Proteins Using a Novel Anti-sulfotyrosine Monoclonal Antibody.
A. J. Hoffhines, E. Damoc, K. G. Bridges, J. A. Leary, and K. L. Moore (2006)
J. Biol. Chem. 281, 37877-37887
   Abstract »    Full Text »    PDF »
Glycoprotein Ib{alpha}-Mediated Platelet Adhesion and Aggregation to Immobilized Thrombin Under Conditions of Flow.
C. Weeterings, J. Adelmeijer, T. Myles, P. G. de Groot, and T. Lisman (2006)
Arterioscler Thromb Vasc Biol 26, 670-675
   Abstract »    Full Text »    PDF »
Directing thrombin.
D. A. Lane, H. Philippou, and J. A. Huntington (2005)
Blood 106, 2605-2612
   Abstract »    Full Text »    PDF »
Effects of Thrombin on Interactions Between {beta}3-Integrins and Extracellular Matrix in Platelets and Vascular Cells.
G.A. Stouffer and S.S. Smyth (2003)
Arterioscler Thromb Vasc Biol 23, 1971-1978
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)