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Science 13 June 2003:
Vol. 300. no. 5626, pp. 1670 - 1671
DOI: 10.1126/science.1086238
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Perspectives

VIROLOGY:
Picking the Right Spot

Didier Trono

Retroviruses ensure that their reverse-transcribed RNA genomes are integrated into the DNA of host cells, a characteristic that has prompted their use as gene-therapy vectors. In a Perspective, Trono discusses new findings (Wu et al.) that describe how two retroviruses, MLV and HIV, show very different sites of integration in the human genome. Trono explains the important implications of these findings for the use of retroviral vectors in gene therapy.

The author is in the Department of Genetics and Microbiology, University of Geneva, Switzerland. E-mail: didier.trono{at}medecine.unige.ch

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
F. Zhang, S. I. Thornhill, S. J. Howe, M. Ulaganathan, A. Schambach, J. Sinclair, C. Kinnon, H. B. Gaspar, M. Antoniou, and A. J. Thrasher (2007)
Blood 110, 1448-1457
   Abstract »    Full Text »    PDF »
Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells.
M. De Palma, E. Montini, F. R. S. de Sio, F. Benedicenti, A. Gentile, E. Medico, and L. Naldini (2005)
Blood 105, 2307-2315
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)