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Science 11 April 2003:
Vol. 300. no. 5617, pp. 263 - 265
DOI: 10.1126/science.1084511
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Perspectives

IMMUNOLOGY:
CD8 T Cells Remember with a Little Help

Susan M. Kaech and Rafi Ahmed

A robust recall response by memory CD8 T cells when they re-encounter antigen is an important way for the immune system to combat bacterial and viral infections. However, CD8 T cells need a little help, as Kaech and Ahmed discuss in their Perspective. During their differentiation, memory CD8 T cells need help from CD4 T cells to ensure formation of a recall response that is robust in both quality and quantity.

The authors are at the Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA. E-mail: ra{at}microbio.emory.edu

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