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Science 4 April 2003:
Vol. 300. no. 5616, pp. 72 - 73
DOI: 10.1126/science.1084034
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Perspectives

STRUCTURAL BIOLOGY:
A Glimpse into tmRNA-Mediated Ribosome Rescue

Sean D. Moore, Kathleen E. McGinness, Robert T. Sauer

Eubacteria use a molecule called tmRNA to rescue ribosomes that stall on mRNA during protein synthesis. In their perspective, Moore et al. discuss new work (Valle et al.) that uses cryo-electron microscopy to determine the structure of tmRNA in complex with the ribosome. The structure gives insight into how tmRNA is able to function as both a tRNA and a mRNA to release the stalled ribosomes.

The authors are in the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: bobsauer{at}.mit.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)