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Science 4 April 2003:
Vol. 300. no. 5616, pp. 65 - 67
DOI: 10.1126/science.1083628
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Perspectives

CELL BIOLOGY:
Apoptosis--the Calcium Connection

Nicolas Demaurex and Clark Distelhorst

Calcium ions are crucial to many cellular processes including apoptosis. In their Perspective, Demaurex and Distelhorst explain new work that shows how calcium ions flowing between the endoplasmic reticulum (ER) and mitochondria regulate programmed cell death, highlighting the ER as a new gateway to apoptosis (Scorrano et al.).

N. Demaurex is in the Department of Physiology, University of Geneva Medical Center, Geneva, Switzerland. E-mail: nicolas.demaurex{at}medecine.unige.ch C. Distelhorst is in the Department of Medicine, Case Western Reserve University Medical School, Cleveland, OH 44106-4937, USA. E-mail: cwd{at}cwru.edu

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