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Science 28 February 2003:
Vol. 299. no. 5611, pp. 1331 - 1333
DOI: 10.1126/science.1082931
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Perspectives

HUMAN GENETICS:
Primate Shadow Play

Richard A. Gibbs and David L. Nelson

Comparing the genome sequences of distantly related species can yield valuable information about the locations of genes and of the control elements that regulate them. In their Perspective, Gibbs and Nelson discuss a new technique called phylogenetic shadowing which enabled comparison of the genome sequences of 17 closely related primate species and Homo sapiens (Boffelli et al.). This method revealed the location of exons and regulatory regions in the human genome with increased precision.

The authors are in the Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. E-mail: agibbs{at}bcm.tmc.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Strong selective sweep associated with a transposon insertion in Drosophila simulans.
T. A. Schlenke and D. J. Begun (2004)
PNAS 101, 1626-1631
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Science. ISSN 0036-8075 (print), 1095-9203 (online)