Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 February 2003:
Vol. 299. no. 5609, pp. 1025 - 1027
DOI: 10.1126/science.1081519
Prev | Table of Contents | Next

Perspectives

SIGNAL TRANSDUCTION:
Imposing Specificity on Kinases

Mark Ptashne and Alexander Gann

How does a cell imbue kinase signaling cascades that share some of the same components with a specificity that ensures activation of the correct cellular response? In their Perspective, Ptashne and Gann discuss the leading part played by protein scaffolds and regulated recruitment in conferring specificity on kinase signaling cascades.

M. Ptashne is in the Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. E-mail: m-ptashne{at}ski.mskcc.org A. Gann is at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. E-mail: ganna{at}csh.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Propofol Depresses Angiotensin II-Induced Cardiomyocyte Hypertrophy In Vitro.
X.-J. Zou, L. Yang, and S.-L. Yao (2008)
Experimental Biology and Medicine 233, 200-208
   Abstract »    Full Text »    PDF »
Multiple Upstream Signals Converge on the Adaptor Protein Mst50 in Magnaporthe grisea.
G. Park, C. Xue, X. Zhao, Y. Kim, M. Orbach, and J.-R. Xu (2006)
PLANT CELL 18, 2822-2835
   Abstract »    Full Text »    PDF »
Rules for Modeling Signal-Transduction Systems.
W. S. Hlavacek, J. R. Faeder, M. L. Blinov, R. G. Posner, M. Hucka, and W. Fontana (2006)
Sci. STKE 2006, re6
   Abstract »    Full Text »    PDF »
Transcriptional activating regions target attached substrates to a cyclin-dependent kinase.
A. Z. Ansari, A. Ogirala, and M. Ptashne (2005)
PNAS 102, 2346-2349
   Abstract »    Full Text »    PDF »
Death-Associated Protein Kinase Phosphorylates ZIP Kinase, Forming a Unique Kinase Hierarchy To Activate Its Cell Death Functions.
G. Shani, L. Marash, D. Gozuacik, S. Bialik, L. Teitelbaum, G. Shohat, and A. Kimchi (2004)
Mol. Cell. Biol. 24, 8611-8626
   Abstract »    Full Text »    PDF »
BRCA1 Interacts with and Is Required for Paclitaxel-Induced Activation of Mitogen-Activated Protein Kinase Kinase Kinase 3.
P. M. Gilmore, N. McCabe, J. E. Quinn, R. D. Kennedy, J. J. Gorski, H. N. Andrews, S. McWilliams, M. Carty, P. B. Mullan, W. P. Duprex, et al. (2004)
Cancer Res. 64, 4148-4154
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)