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Science 14 February 2003:
Vol. 299. no. 5609, pp. 1002 - 1006
DOI: 10.1126/science.299.5609.1002
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News Focus

MEDICINE:
Tracing the Steps of Metastasis, Cancer's Menacing Ballet

Jennifer Couzin

Recent studies have unexpectedly found that a constellation of molecular signals in cancer cells and the patient's own body steer tumor cells, bit by bit, from the primary site to a new, ideal home. Large-scale gene studies are suggesting fundamental differences between such metastatic cells and other cancer cells. Researchers are also taking a deeper look at electrifying similarities between embryonic and metastatic cells.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gastric Cancer Originating from Bone Marrow-Derived Cells.
J. Houghton, C. Stoicov, S. Nomura, A. B. Rogers, J. Carlson, H. Li, X. Cai, J. G. Fox, J. R. Goldenring, and T. C. Wang (2004)
Science 306, 1568-1571
   Abstract »    Full Text »    PDF »
A Fasciclin 2 morphogenetic switch organizes epithelial cell cluster polarity and motility.
P. Szafranski and S. Goode (2004)
Development 131, 2023-2036
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)