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Science 17 January 2003:
Vol. 299. no. 5605, pp. 333 - 335
DOI: 10.1126/science.299.5605.333
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News Focus

NEUROSCIENCE:
Deconstructing Schizophrenia

Constance Holden

After decades of research, no one knows the cause of schizophrenia, many efforts to unravel the genetics behind it have ended in frustration, and no cure is in sight. But in recent years, scientists have made significant gains--not by tackling the disease head-on but by picking apart its components, especially those involved in cognition. And this has given them hope that they might finally be able to unlock some of schizophrenia's intractable secrets.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metabolism and Disposition of a Selective {alpha}7 Nicotinic Acetylcholine Receptor Agonist in Humans.
C. L. Shaffer, M. Gunduz, R. J. Scialis, and A. F. Fang (2007)
Drug Metab. Dispos. 35, 1188-1195
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Nonfunctional Glial Proteins in Tripartite Synapses: A Pathophysiological Model of Schizophrenia.
B. Mitterauer (2005)
Neuroscientist 11, 192-198
   Abstract »    PDF »
Metachromatic Leukodystrophy: A Model for the Study of Psychosis.
D. N. Black, K. H. Taber, and R. A. Hurley (2003)
J Neuropsychiatry Clin Neurosci 15, 289-293
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Science. ISSN 0036-8075 (print), 1095-9203 (online)