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The low density lipoprotein receptor (LDLR) binds to lipoprotein extracellularly and releases it in the endosome. In his Perspective, Innerarity discusses new structural work (Rudenkoet al.) that shows that an interdomain interaction that occurs at low pH likely displaces ligand from the receptor in the endosome.
The author is at the Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94110, USA. E-mail: tinnerarity{at}gladstone.ucsf.edu
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