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Science 13 December 2002:
Vol. 298. no. 5601, pp. 2116 - 2120
DOI: 10.1126/science.298.5601.2116
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News Focus

GENE THERAPY:
The Strange Case of Chimeraplasty

Gary Taubes

In 1996, Science published an article that described a radical new technology for correcting genetic defects, one that appeared to be a million-fold more potent than previous approaches were. The publication caught the media's attention, launched research projects around the world, and spawned a gold rush as researchers and entrepreneurs moved to stake their claim to the extraordinary promise of the technology. But the technique has turned out to be inconsistent or impossible to replicate in most labs that have tried it.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Mouse Retina Has Oligonucleotide-Induced Gene Repair Activity.
V. T. Ciavatta, S. A. Padove, J. H. Boatright, and J. M. Nickerson (2005)
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Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector.
G. Toietta, V. P. Mane, W. S. Norona, M. J. Finegold, P. Ng, A. F. McDonagh, A. L. Beaudet, and B. Lee (2005)
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Increased efficiency of oligonucleotide-mediated gene repair through slowing replication fork progression.
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PNAS 102, 2508-2513
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Reversal of cystic fibrosis phenotype in a cultured {Delta}508 cystic fibrosis transmembrane conductance regulator cell line by oligonucleotide insertion.
P. C. Zamecnik, M. K. Raychowdhury, D. R. Tabatadze, and H. F. Cantiello (2004)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)