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Science 6 December 2002:
Vol. 298. no. 5600, p. 1843
DOI: 10.1126/science.298.5600.1843k
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This Week in Science

The widespread resistance of human malaria parasite Plasmodium falciparum to the few effective antimalarial drugs has led to a search for new therapeutic targets. Greenbaum et al. (p. 2002) used a chemical proteomics screen to identify a cysteine protease, falcipain-1, that is essential for the parasite merozoites to invade human red blood cells. By screening chemical libraries, the authors identified inhibitors that specifically blocked only falcipain-1 activity and parasite invasion of erythrocytes, but not other cysteine proteases or other stages in the parasite life cycle.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)