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Science 15 November 2002:
Vol. 298. no. 5597, pp. 1324 - 1325
DOI: 10.1126/science.298.5597.1324
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News Focus

POPULATION GENETICS:
Seeking the Signs of Selection

Steve Olson

Efficient sequencing techniques and the almost complete human genome sequence are spurring the search for evidence of natural selection at work in human prehistory. They have already helped add several new genes to the list of those affected by selection. And because some of the most potent selective forces have been pathogens, researchers are hoping the search will help them zero in on parts of the genome involved in disease.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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The ANNALS of the American Academy of Political and Social Science 614, 34-55
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ADHD characteristics in canadian aboriginal children..
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J Atten Disord 9, 642-647
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VariScan: Analysis of evolutionary patterns from large-scale DNA sequence polymorphism data.
A. J. Vilella, A. Blanco-Garcia, S. Hutter, and J. Rozas (2005)
Bioinformatics 21, 2791-2793
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Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia.
B. A. Kerlin, S. B. Yan, B. H. Isermann, J. T. Brandt, R. Sood, B. R. Basson, D. E. Joyce, H. Weiler, and J.-F. Dhainaut (2003)
Blood 102, 3085-3092
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Large-Scale Adaptive Hitchhiking Upon High Recombination in Drosophila simulans.
H. Quesada, U. E. M. Ramirez, J. Rozas, and M. Aguade (2003)
Genetics 165, 895-900
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Science. ISSN 0036-8075 (print), 1095-9203 (online)