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Science 25 October 2002:
Vol. 298. no. 5594, pp. 728 - 731
DOI: 10.1126/science.298.5594.728
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News Focus

BACTERIOPHAGE THERAPY:
Stalin's Forgotten Cure

Richard Stone

TBILISI--Bacteriophage therapy, pioneered in Stalin-era Russia, is attracting renewed attention in the West as a potential weapon against drug-resistant bugs and hard-to-treat infections. Phages--viruses that infect bacteria--could soon find a role as a treatment for burns, diabetic ulcers, and other open wounds, although experts concur that these viral breeds are unlikely to knock antibiotics off their pedestal for most infections.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antitumor Effect of Combined Treatment of Mice with Cytostatic Agents and Bacteriophage T4.
K. SZCZAURSKA-NOWAK, K. DABROWSKA, M. CELKA, A. KURZEPA, D. NEVOZHAY, J. WIETRZYK, K. SWITALA-JELEN, D. SYPER, G. POZNIAK, A. OPOLSKI, et al. (2009)
Anticancer Res 29, 2361-2370
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Phage-Mediated Intergeneric Transfer of Toxin Genes.
J. Chen and R. P. Novick (2009)
Science 323, 139-141
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Morphological and Genetic Diversity of Temperate Phages in Clostridium difficile.
L.-C. Fortier and S. Moineau (2007)
Appl. Envir. Microbiol. 73, 7358-7366
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Phage_Finder: Automated identification and classification of prophage regions in complete bacterial genome sequences.
D. E. Fouts (2006)
Nucleic Acids Res. 34, 5839-5851
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Genomic Analysis of Pseudomonas aeruginosa Phages LKD16 and LKA1: Establishment of the {phi}KMV Subgroup within the T7 Supergroup..
P.-J. Ceyssens, R. Lavigne, W. Mattheus, A. Chibeu, K. Hertveldt, J. Mast, J. Robben, and G. Volckaert (2006)
J. Bacteriol. 188, 6924-6931
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In Vitro and In Vivo Bacteriolytic Activities of Escherichia coli Phages: Implications for Phage Therapy.
S. Chibani-Chennoufi, J. Sidoti, A. Bruttin, E. Kutter, S. Sarker, and H. Brussow (2004)
Antimicrob. Agents Chemother. 48, 2558-2569
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Longitudinal Study of Campylobacter jejuni Bacteriophages and Their Hosts from Broiler Chickens.
P. L. Connerton, C. M. Loc Carrillo, C. Swift, E. Dillon, A. Scott, C. E. D. Rees, C. E. R. Dodd, J. Frost, and I. F. Connerton (2004)
Appl. Envir. Microbiol. 70, 3877-3883
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)