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Science 18 October 2002:
Vol. 298. no. 5593, pp. 510 - 511
DOI: 10.1126/science.298.5593.510
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News of the Week

GENE THERAPY:
What to Do When Clear Success Comes With an Unclear Risk?

Eliot Marshall

An expert panel, meeting in an emergency session last week, urged the U.S. Food and Drug Administration to lift a hold it had placed on three gene therapy trials after a patient treated with gene therapy in France developed cancer. The panel made the recommendation after concluding that the cancer was almost certainly caused by the gene therapy.

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Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human {beta}-globin transgene in a centromeric region.
S.-H. L. Kang, P. P Levings, F. Andersen, P. J Laipis, K. I Berns, R. T Zori, and J. Bungert (2004)
Genes Cells 9, 1043-1053
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Endocrine Aspects of Cancer Gene Therapy.
L. Barzon, M. Boscaro, and G. Palu (2004)
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A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia.
A. Ehrhardt, H. Xu, A. M. Dillow, D. A. Bellinger, T. C. Nichols, and M. A. Kay (2003)
Blood 102, 2403-2411
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The new frontier in muscular dystrophy research: booster genes.
E. ENGVALL and U. M. WEWER (2003)
FASEB J 17, 1579-1584
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