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BIOMEDICINE: Gluten and the Gut--Lessons for Immune Regulation
Detlef Schuppan and Eckhart G. Hahn
Celiac sprue is a common disease in which an immune response to the gluten in wheat results in an inflammatory reaction in the small intestine that can prevent the absorption of nutrients. In a Perspective, Schuppan and Hahn discuss new work (Shanet al.) that identifies a 33-amino acid peptide in gluten that contains the major immunogenic epitopes. This discovery opens the door to developing therapeutic strategies to treat celiac sprue by destroying this peptide.
The authors are in the First Department of Medicine, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany. E-mail: detlef.schuppan{at}med1.imed.uni-erlangen.de
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In Science Magazine
REPORTS
Lu Shan, Øyvind Molberg, Isabelle Parrot, Felix Hausch, Ferda Filiz, Gary M. Gray, Ludvig M. Sollid, and Chaitan Khosla (27 September 2002) Science297 (5590), 2275.
[DOI: 10.1126/science.1074129] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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