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Science 27 September 2002:
Vol. 297. no. 5590, pp. 2218 - 2220
DOI: 10.1126/science.1077572
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Perspectives

BIOMEDICINE:
Gluten and the Gut--Lessons for Immune Regulation

Detlef Schuppan and Eckhart G. Hahn

Celiac sprue is a common disease in which an immune response to the gluten in wheat results in an inflammatory reaction in the small intestine that can prevent the absorption of nutrients. In a Perspective, Schuppan and Hahn discuss new work (Shan et al.) that identifies a 33-amino acid peptide in gluten that contains the major immunogenic epitopes. This discovery opens the door to developing therapeutic strategies to treat celiac sprue by destroying this peptide.

The authors are in the First Department of Medicine, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany. E-mail: detlef.schuppan{at}med1.imed.uni-erlangen.de

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IgA antibodies of coeliac disease patients recognise a dominant T cell epitope of A-gliadin.
E A L Bateman, B L Ferry, A Hall, S A Misbah, R Anderson, and P Kelleher (2004)
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Diabetes Care 26, 1932-1939
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Celiac Disease Association with CD8+ T Cell Responses: Identification of a Novel Gliadin-Derived HLA-A2-Restricted Epitope.
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Triggering Molecule in Celiac Disease Is Identified.
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Journal Watch (General) 2002, 4
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Science. ISSN 0036-8075 (print), 1095-9203 (online)