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MOLECULAR BIOLOGY: An RNA-Guided Pathway for the Epigenome
Thomas Jenuwein
How does the cell maintain the huge areas of the genome containing DNA repeats in its heterochromatin form? As Thomas Jenuwein discusses in his indepth Perspective, new clues have arrived from the fission yeast (Hallet al.) and the ciliated protozoan Tetrahymena. These organisms reveal that small heterogeneous RNAs formed at DNA repeats in the nucleus are important for initiating and maintaining heterochromatin.
The author is with the Research Institute of Molecular Pathology (IMP), Vienna Biocenter, Dr. Bohrgasse 7, A-1030 Vienna, Austria. E-mail: jenuwein{at}nt.imp.univie.ac.at
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