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Science 20 September 2002:
Vol. 297. no. 5589, pp. 2006 - 2008
DOI: 10.1126/science.1077011
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Perspectives

IMMUNOLOGY:
Autoreactive B Cells Migrate into T Cell Territory

Yang-Xin Fu and Ursula Storb

Autoreactive B cells producing antibody against self-antigen are normally deleted by apoptosis. In their Perspective, Fu and Storb discuss new work (William et al.), which shows that in a mouse strain prone to developing autoimmune disease, autoreactive B cells avoid deletion by accumulating in the T cell zone of the spleen instead of in B cell follicles.

Y.-X. Fu is in the Department of Pathology and U. Storb is in the Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA. E-mail: stor{at}midway.uchicago.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hyperresponsiveness, Resistance to B-Cell Receptor--Dependent Activation-Induced Cell Death, and Accumulation of Hyperactivated B-Cells in Islets Is Associated With the Onset of Insulitis but not Type 1 Diabetes.
S. Hussain, K. V. Salojin, and T. L. Delovitch (2004)
Diabetes 53, 2003-2011
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Science. ISSN 0036-8075 (print), 1095-9203 (online)