Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 September 2002:
Vol. 297. no. 5588, pp. 1820 - 1821
DOI: 10.1126/science.1076865
Prev | Table of Contents | Next

Perspectives

BIOCHEMISTRY:
Sense and Sensitivity--Controlling the Ribosome

Matthew S. Sachs and Adam P. Geballe

What regulates the ribosome, the protein synthesis factory of the cell? In a Perspective, Sachs and Geballe discuss new findings (Gong and Yanofsky) that reveal how certain newly forming peptides are able to halt the ribosome from within, for the purpose of controlling gene expression.

M. S. Sachs is in the Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA. E-mail: msachs{at}bmb.ogi.edu. A. P. Geballe is in the Division of Human Biology, Fred Hutchinson Cancer Center and the University of Washington, Seattle, WA 98109, USA. E-mail: ageballe{at}fhcrc.org.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A nascent polypeptide domain that can regulate translation elongation.
P. Fang, C. C. Spevak, C. Wu, and M. S. Sachs (2004)
PNAS 101, 4059-4064
   Abstract »    Full Text »    PDF »
Antagonistic signals within the COX2 mRNA coding sequence control its translation in Saccharomyces cerevisiae mitochondria.
E. H. WILLIAMS and T. D. FOX (2003)
RNA 9, 419-431
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)