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Is the regulation of gene expression in a cell a random (stochastic) process? In an ambitious Perspective, Fedoroff and Fontana explore a new study (Elowitz et al.) that provides experimental evidence for stochasticity in bacterial gene expression. They reflect on the importance of stochastic processes for the evolution and adaptation of organisms.
N. Fedoroff is at Penn State University, University Park, PA 16803, USA. E-mail: nvf1{at}psu.edu W. Fontana is at Santa Fe Institute, Santa Fe, NM 87501, USA. E-mail: walter{at}santafe.edu
Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience.
T. P. O'Brien, C. J. Bult, C. Cremer, M. Grunze, B. B. Knowles, J. Langowski, J. McNally, T. Pederson, J. C. Politz, A. Pombo, et al. (2003)
Genome Res.
13, 1029-1041
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