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Science 16 August 2002:
Vol. 297. no. 5584, pp. 1128 - 1129
DOI: 10.1126/science.1075452
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Perspectives

BIOMEDICINE:
Contact—How Platelets Touch von Willebrand Factor

J. Evan Sadler

The initiation of clotting at sites of vascular injury involves the adhesion of platelets to von Willebrand factor (VWF) via the surface glycoprotein GPIba. In a Perspective, Sadler discusses a new structural analysis (Huizinga et al.) that sheds light on how platelet GPIba interacts with VWF.

The author is in the Department of Medicine, Department of Biochemistry and Molecular Biophysics, and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. E-mail: esadler{at}im.wustl.edu

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