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Science 16 August 2002:
Vol. 297. no. 5584, pp. 1116 - 1118
DOI: 10.1126/science.297.5584.1116
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News Focus

DRUG TARGETING:
Breaking Down Barriers

Greg Miller

The brain is guarded by a nearly impenetrable cellular barrier called the blood-brain barrier. A small but growing community of predominantly academic researchers is studying this barrier with an eye to improving drug delivery to the brain. Their research ranges from trying to better understand the basic biology to creating molecular Trojan horses that sneak anything from neural growth factors to therapeutic genes into the brain.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuroprotection by Small Molecule Activators of the Nerve Growth Factor Receptor.
B. Lin, M. C. Pirrung, L. Deng, Z. Li, Y. Liu, and N. J. G. Webster (2007)
J. Pharmacol. Exp. Ther. 322, 59-69
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Modulation of p-Glycoprotein Transport Function at the Blood-Brain Barrier.
B. Bauer, A. M. S. Hartz, G. Fricker, and D. S. Miller (2005)
Experimental Biology and Medicine 230, 118-127
   Abstract »    Full Text »    PDF »
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice.
T. Nitta, M. Hata, S. Gotoh, Y. Seo, H. Sasaki, N. Hashimoto, M. Furuse, and S. Tsukita (2003)
J. Cell Biol. 161, 653-660
   Abstract »    Full Text »    PDF »
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress.
A. Y. Shih, D. A. Johnson, G. Wong, A. D. Kraft, L. Jiang, H. Erb, J. A. Johnson, and T. H. Murphy (2003)
J. Neurosci. 23, 3394-3406
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)